Depression/Mood Disorders

Know More: Depression and Mood Disorders

Trustworthy information, straight from the source. Education is the first step in an empowering healthcare plan. Learn more about depression and mood disorders from prevention to diagnosis and treatment.

Sad woman meets with provider

Condition Overview

What is depression?

Depression is a broad range of mental health conditions marked by the loss of interest and pleasure in activities, mood disturbance, and an array of related cognitive, emotional, behavioral, and physical symptoms. While the primary causes of mood disorders remain unknown, the common theories fall into three categories: neurobiological factors, psychosocial factors, and familial factors (genetic and environmental).

It is likely the interplay of various factors, rather than any single factor alone, underlies these disorders. Major depressive disorder usually coexists with other psychiatric disorders, such as anxiety disorder (most common), substance abuse disorders, personality disorders, and impulse control disorders.

Depression may also occur in the presence of a medical condition or illness.

Diagnosis & Treatment Options

What are the signs and symptoms of depression?

Common signs and symptoms are insomnia or hypersomnia, fatigue, energy loss, weight changes, difficulty concentrating, restlessness (psychomotor agitation) or slowed movements (psychomotor retardation), feelings of guilt, and recurrent thoughts of death.

How is depression diagnosed?

A thorough clinical evaluation of patients with suspected depression includes:

  • A history of the present illness and current symptoms, including questions about suicidal thoughts, intent, and plans.
  • Psychiatric history, including any manic and hypomanic episodes.
  • General medical history.
  • Any precipitating events, such as significant changes in life circumstance or other life event.
  • Family history, including mood disorders and suicide.
  • Alcohol or other drug usage.
  • Review of any prescribed and over-the-counter medications.
  • Review of systems.
  • Mental status examination and physical examination.

How is depression treated?

Treatment is divided into three phases, each corresponding to a stage of the illness:

  • An acute phase, during which remission is induced.
  • A continuation phase, during which remission is preserved and relapse is averted.
  • A maintenance phase, during which recurrence is averted.

Treatment options for the management of depression include pharmacologic and nonpharmacologic approaches, administered either alone or in combination. Antidepressants are usually the first-line therapy for patients with mild to moderate major depressive disorder (MDD) and are indicated for patients with severe MDD.

Nonpharmacologic approaches include psychotherapy, ECT, light therapy, prescribed exercise, and transcranial magnetic stimulation. Psychotherapy may be considered.

Preparing for Care

How can I manage depression?

  • Get regular physical activity. Try to exercise for 30 minutes, three to five days a week. Work with your healthcare provider to develop an exercise plan that you enjoy. Physical activity may improve your symptoms.
  • Get enough sleep. Create a routine to help you relax before bed. You can listen to music, read, or do yoga. Try to go to bed and wake up at the same time every day. Sleep is important for emotional health.
  • Eat a variety of healthy foods from all of the food groups. A healthy meal plan is low in fat, salt, and added sugar. Ask your healthcare provider for more information about a meal plan that is right for you.
  • Do not drink alcohol or use drugs. Alcohol and drugs can make your symptoms worse.

When should I contact my healthcare provider?

  • Your symptoms do not improve.
  • You have new symptoms.
  • You have questions or concerns about your condition or care.

Call 911 if you are thinking about harming yourself or someone else.

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